Search results for "ex vivo model"

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Ex-Vivo model for the evaluation of drugs and micellar systems permeation across cornea

ex vivo model franz type cells bovine corneas micelles drug deliverySettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Buccal Thin Films as Potent Permeation Enhancers for Cytisine Transbuccal Delivery

2022

Cytisine (CYT) is a powerful anti-smoking compound which could greatly benefit from transbuccal delivery because of both its unfavorable pharmacokinetics after oral administration and its intrinsic ability to permeate the buccal mucosa. This work aims to design CYT-loaded buccal thin films suitable for transbuccal drug delivery due to its capability of promoting the interaction between CYT and the buccal membrane. The solvent casting method was employed to prepare several thin films combining various excipients such as matrixing polymers, mucoadhesion agents, plasticizers and other compounds as humectants and sweeteners, component ratios and solvents. A total of 36 compositions was prepared…

permeation enhancerdrug-membrane interactionbuccal filmSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoProcess Chemistry and Technologycytisinecytisine; buccal film; transmucosal drug delivery; drug-membrane interaction; permeability; mucoadhesion; permeation enhancer; ex vivo modelChemical Engineering (miscellaneous)Filtration and Separationpermeabilityex vivo modeltransmucosal drug deliverymucoadhesionMembranes; Volume 12; Issue 11; Pages: 1169
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